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Prof. Kohji Seio
School of Life Science and Technology
Associate Prof. Yoshiaki Masaki
School of Life Science and Technology

The research into nucleic acid drugs, which began in the latter half of the 20th century, has begun to yield fruit recently, and over the last few years, new blockbuster drugs such as Exondys 51, Spinraza, Onpattro, and Tegsedi have been approved. On the other hand, due to unresolved issues such as poor pharmacokinetics and toxicity of nucleic acid molecules, the full potential of nucleic acid drugs has not yet been realized.
In this project, we are working to achieve new breakthroughs in nucleic acid drugs by developing nucleic acid drug discovery technology that combines proprietary artificial nucleic acids with in silico toxicity prediction technology.