Prof. Yuki Yamaguchi School of Life Science and Technology	Assistant Prof. Satoshi Sakamoto School of Life Science and Technology

In drug discovery, the selection of target molecules (proteins) is an important aspect that can mark the difference between success and failure of drug development. Since middle molecule drugs do not depend on intracellular localization and 3D structural information of target proteins, unlike small molecule drugs and antibody drugs, proteins that were not previously considered as drug targets may actually be such, making it necessary to come up with new ideas. We have developed a method of identifying drug target molecules through unbiased screening using magnetic nanobeads. At MIDL, we are endeavoring to search and identify new drug targets for middle molecule drug discovery, and are planning to contribute to middle molecule drug discovery by conducting safety tests of middle molecule lead compounds (evaluation of side effects and off-target effects) using magnetic nanobeads.